Spinal cord injury (SCI) at high spinal levels (eg, above thoracic level 5) causes systemic
immune suppression; however, the underlying mechanisms are unknown. Here we show …

Autonomic dysreflexia (AD), a potentially dangerous complication of high-level spinal cord
injury (SCI) characterized by exaggerated activation of spinal autonomic (sympathetic) …

Spinal cord injury (SCI) disrupts critical physiological systems, including the cardiovascular
and immune system. Plasticity of spinal circuits below the injury results in abnormal …

Simple Summary Spinal cord injury can result in an increased vulnerability to infections, but
until recently the biological mechanisms behind this observation were not well defined …

Traumatic spinal cord injury (SCI) impedes signal transmission by disrupting both the local
neurons and their surrounding synaptic connections. Although the majority of SCI patients …

After spinal cord injury (SCI), normally innocuous visceral or somatic stimuli can trigger
uncontrolled reflex activation of sympathetic circuitry, causing pathological dysautonomia …

Severe spinal cord injury in adults leads to irreversible paralysis below the lesion. However,
adult rodents that received a complete thoracic lesion just after birth demonstrate proficient …

Many human spinal cord injuries are anatomically incomplete but exhibit complete paralysis.
It is unknown why spared axons fail to mediate functional recovery in these cases. To …

Spinal cord injury (SCI) caused by a crush, cut, or blow to the spinal cord is a devastating
event that results in permanent functional deficits. SCI damages multiple structures at the …

Cardiovascular disease and susceptibility to infection are leading causes of morbidity and
mortality for individuals with spinal cord injury (SCI). A major contributor to these is …