Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases

ZA Kohutek, Y Yamada, TA Chan, CW Brennan… - Journal of neuro …, 2015 - Springer
Radionecrosis is a well-characterized effect of stereotactic radiosurgery (SRS) and is
occasionally associated with serious neurologic sequelae. Here, we investigated the …

Association between radiation necrosis and tumor biology after stereotactic radiosurgery for brain metastasis

JA Miller, EE Bennett, R Xiao, R Kotecha… - International Journal of …, 2016 - Elsevier
Background The primary dose-limiting toxicity of stereotactic radiosurgery (SRS) is radiation
necrosis (RN), which occurs after approximately 5% to 10% of treatments. This adverse …

Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgery

BJ Blonigen, RD Steinmetz, L Levin, MA Lamba… - International Journal of …, 2010 - Elsevier
PURPOSE: To investigate the correlation between volume of brain irradiated by stereotactic
radiosurgery (SRS) and the incidence of symptomatic and asymptomatic brain radionecrosis …

Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors

PK Sneed, J Mendez, JGM Vemer-van den Hoek… - Journal of …, 2015 - thejns.org
OBJECT The authors sought to determine the incidence, time course, and risk factors for
overall adverse radiation effect (ARE) and symptomatic ARE after stereotactic radiosurgery …

Incidence of radionecrosis in single-fraction radiosurgery compared with fractionated radiotherapy in the treatment of brain metastasis

EK Donovan, S Parpia, JN Greenspoon - Current Oncology, 2019 - mdpi.com
Introduction: RIntroductionadiation-induced brain necrosis [“radionecrosis”(RN)] is a
relatively uncommon but potentially severe adverse effect of stereotactic radiosurgery (SRS) …

The risk of radiation necrosis following stereotactic radiosurgery with concurrent systemic therapies

JM Kim, JA Miller, R Kotecha, R Xiao, A Juloori… - Journal of neuro …, 2017 - Springer
To investigate late toxicity among patients with newly-diagnosed brain metastases
undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or …

Radionecrosis induced by stereotactic radiosurgery of brain metastases: results of surgery and outcome of disease

S Telera, A Fabi, A Pace, A Vidiri, V Anelli… - Journal of neuro …, 2013 - Springer
Sterotactic radiosurgery (SRS) is an effective and commonly employed therapy for
metastatic brain tumors. Among complication of this treatment, symptomatic focal cerebral …

Single-fraction versus multifraction (3× 9 Gy) stereotactic radiosurgery for large (> 2 cm) brain metastases: a comparative analysis of local control and risk of radiation …

G Minniti, C Scaringi, S Paolini, G Lanzetta… - International Journal of …, 2016 - Elsevier
Purpose To investigate the local control and radiation-induced brain necrosis in patients
with brain metastases> 2 cm in size who received single-fraction or multifraction stereotactic …

Conventional MRI does not reliably distinguish radiation necrosis from tumor recurrence after stereotactic radiosurgery

AL Stockham, AL Tievsky, SA Koyfman… - Journal of neuro …, 2012 - Springer
Distinguishing radiation necrosis (RN) from tumor recurrence after stereotactic radiosurgery
(SRS) for brain metastases is challenging. This study assesses the sensitivity (SN) and …

Radionecrosis after stereotactic radiotherapy for brain metastases

E Le Rhun, F Dhermain, G Vogin, N Reyns… - Expert review of …, 2016 - Taylor & Francis
Introduction: Radionecrosis (RN) represents the main complication of stereotactic
radiotherapy (SRT) for brain metastases. It may be observed in up to 34% of cases at 24 …