Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice
In Parkinson's disease (PD), axons of dopaminergic (DA) neurons in the substantia nigra
pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker …
pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker …
[PDF][PDF] Aberrant somatic L-and T-type calcium channel function in cNurr1 and LRRK2-G2019S mice
In Parkinson's disease (PD), axons of dopaminergic (DA) neurons in the substantia nigra
pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker …
pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker …
LRRK2‐G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons
The progressive degeneration of dopamine (DA) neurons in the substantia nigra compacta
(SNc) leads to the emergence of motor symptoms in patients with Parkinson's disease (PD) …
(SNc) leads to the emergence of motor symptoms in patients with Parkinson's disease (PD) …
[PDF][PDF] L-type calcium channel contribution to striatal dopamine release is governed by calbindin-D28K, the dopamine transporter, D2-receptors, α2δ-subunits and sex …
Abstract 1 Ca2+ entry to nigrostriatal dopamine (DA) neurons and axons via L-type voltage-
gated Ca2+ channels 2 (LTCCs) contributes to pacemaker activity and DA release, but …
gated Ca2+ channels 2 (LTCCs) contributes to pacemaker activity and DA release, but …
Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice
Dopamine (DA) release in striatum is functionally segregated across a dorsolateral/
ventromedial axis. Interestingly, nigrostriatal DA signaling disruption in Parkinson's disease …
ventromedial axis. Interestingly, nigrostriatal DA signaling disruption in Parkinson's disease …
Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons
E Dragicevic, C Poetschke, J Duda, F Schlaudraff… - Brain, 2014 - academic.oup.com
Dopamine midbrain neurons within the substantia nigra are particularly prone to
degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms …
degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms …
Dopamine inhibition differentially controls excitability of substantia nigra dopamine neuron subpopulations through T-type calcium channels
While there is growing appreciation for diversity among ventral tegmental area dopamine
neurons, much less is known regarding functional heterogeneity among the substantia nigra …
neurons, much less is known regarding functional heterogeneity among the substantia nigra …
Lower affinity of isradipine for L-type Ca2+ channels during substantia nigra dopamine neuron-like activity: implications for neuroprotection in Parkinson's disease
NJ Ortner, G Bock, A Dougalis… - Journal of …, 2017 - Soc Neuroscience
Ca2+-influx through L-type Ca2+-channels (LTCCs) is associated with activity-related
stressful oscillations of Ca2+ levels within dopaminergic (DA) neurons in the substantia …
stressful oscillations of Ca2+ levels within dopaminergic (DA) neurons in the substantia …
Inhibition of striatal dopamine release by the L‐type calcium channel inhibitor isradipine co‐varies with risk factors for Parkinson's
KR Brimblecombe, N Connor‐Robson… - European Journal of …, 2024 - Wiley Online Library
Ca2+ entry into nigrostriatal dopamine (DA) neurons and axons via L‐type voltage‐gated
Ca2+ channels (LTCCs) contributes, respectively, to pacemaker activity and DA release and …
Ca2+ channels (LTCCs) contributes, respectively, to pacemaker activity and DA release and …
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease
LA Matschke, MA Komadowski, A Stöhr, B Lee… - Scientific Reports, 2022 - nature.com
Parkinson's disease (PD) is clinically defined by the presence of the cardinal motor
symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the …
symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the …