The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …

Haematopoietic stem cells drive blood production, but their population size and lifetime
dynamics have not been quantified directly in humans. Here we identified 129,582 …

Haematopoiesis, the process of mature blood and immune cell production, is functionally
organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent …

It is currently thought that life-long blood cell production is driven by the action of a small
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …

Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The
number of HSC clones born has been estimated through transplantation, but experimental …

Haematopoietic stem cells (HSCs) are widely studied by HSC transplantation into immune-
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge in …

Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …