RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation
Cardiotoxicity remains a major limitation in the clinical utility of anthracycline
chemotherapeutics. Regulator of G-protein Signaling 7 (RGS7) and inflammatory markers …
chemotherapeutics. Regulator of G-protein Signaling 7 (RGS7) and inflammatory markers …
[HTML][HTML] RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis
Dose limiting cardiotoxicity remains a major limiting factor in the clinical use of several
cancer chemotherapeutics including anthracyclines and the antimetabolite 5-fluorouracil (5 …
cancer chemotherapeutics including anthracyclines and the antimetabolite 5-fluorouracil (5 …
A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity
M Basak, AS Sengar, K Das, T Mahata… - Proceedings of the …, 2023 - National Acad Sciences
Dose-limiting cardiotoxicity remains a major limitation in the clinical use of cancer
chemotherapeutics. Here, we describe a role for Regulator of G protein Signaling 7 (RGS7) …
chemotherapeutics. Here, we describe a role for Regulator of G protein Signaling 7 (RGS7) …
RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21
Background Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6)
translocates to the nucleolus in response to cytotoxic stress though the functional …
translocates to the nucleolus in response to cytotoxic stress though the functional …
Two for the price of one: G protein-dependent and-independent functions of RGS6 in vivo
Regulator of G protein signaling 6 (RGS6) is unique among the members of the RGS protein
family as it remains the only protein with the demonstrated capacity to control G protein …
family as it remains the only protein with the demonstrated capacity to control G protein …
Cardiac RGS7 and RGS11 drive TGFβ1‐dependent liver damage following chemotherapy exposure
K Das, M Basak, T Mahata, S Biswas… - The FASEB …, 2023 - Wiley Online Library
Off target damage to vital organ systems is an unfortunate side effect of cancer
chemotherapy and remains a major limitation to the use of these essential drugs in the clinic …
chemotherapy and remains a major limitation to the use of these essential drugs in the clinic …
G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin
Clinical use of the widely used chemotherapeutic agent doxorubicin is limited by life-
threatening cardiotoxicity. The mechanisms underlying doxorubicin-induced …
threatening cardiotoxicity. The mechanisms underlying doxorubicin-induced …
Atypical G protein β5 promotes cardiac oxidative stress, apoptosis, and fibrotic remodeling in response to multiple cancer chemotherapeutics
S Chakraborti, A Pramanick, S Saha, SS Roy… - Cancer Research, 2018 - AACR
The clinical use of multiple classes of cancer chemotherapeutics is limited by irreversible,
dose-dependent, and sometimes life-threatening cardiotoxicity. Though distinct in their …
dose-dependent, and sometimes life-threatening cardiotoxicity. Though distinct in their …
RGS proteins in heart: brakes on the vagus
It has been nearly a century since Otto Loewi discovered that acetylcholine (ACh) release
from the vagus produces bradycardia and reduced cardiac contractility. It is now known that …
from the vagus produces bradycardia and reduced cardiac contractility. It is now known that …
Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species–dependent mechanism
J Huang, J Yang, B Maity, D Mayuzumi, RA Fisher - Cancer research, 2011 - AACR
Doxorubicin (DXR), among the most widely used cancer chemotherapy agents, promotes
cancer cell death via activation of ataxia telangiectasia mutated (ATM) and the resultant …
cancer cell death via activation of ataxia telangiectasia mutated (ATM) and the resultant …