Associations of enlarged perivascular spaces with brain lesions, brain age, and clinical outcomes in chronic traumatic brain injury

AJ Hicks, B Sinclair, SR Shultz, W Pham, LC Silbert… - Neurology, 2023 - AAN Enterprises
Background and Objectives Enlarged perivascular spaces (ePVS) have been identified as a
key signature of glymphatic system dysfunction in neurologic conditions. The incidence and …

Neuropathologic and cognitive correlates of enlarged perivascular spaces in a community-based cohort of older adults

C Javierre-Petit, JA Schneider, A Kapasi, N Makkinejad… - Stroke, 2020 - Am Heart Assoc
Background and Purpose: Enlarged perivascular spaces (EPVS) have been associated with
aging, increased stroke risk, decreased cognitive function, and vascular dementia. However …

Enlarged perivascular spaces are associated with health‐related quality of life in patients with acute ischemic stroke

Y Liang, M Deng, YK Chen, V Mok… - CNS neuroscience & …, 2017 - Wiley Online Library
Aims This study explored the association between enlarged perivascular spaces (EPVS)
and the health‐related quality of life (HRQ oL) in patients with acute ischemic stroke …

Enlarged perivascular spaces are associated with cognitive function in healthy elderly men

AMJ MacLullich, JM Wardlaw, KJ Ferguson… - Journal of Neurology …, 2004 - jnnp.bmj.com
Objectives: Increased white matter (WM) lesions on magnetic resonance imaging (MRI) are
associated with worse cognitive function in older people. Enlarged perivascular spaces …

Enlarged perivascular spaces and dementia: a systematic review

D Smeijer, MK Ikram, S Hilal - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Perivascular compartments surrounding the penetrating arteries in the brain are part of a
physiologic system, which facilitates fluids exchange and clearance of solutes from the …

Association of dilated perivascular spaces with cognitive decline and incident dementia

M Paradise, JD Crawford, BCP Lam, W Wen… - Neurology, 2021 - AAN Enterprises
Objective To determine whether severe perivascular space (PVS) dilation is associated with
longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we …

The relationship between enlarged perivascular spaces and cognitive function: a meta-analysis of observational studies

W Jie, G Lin, Z Liu, H Zhou, L Lin, G Liang… - Frontiers in …, 2020 - frontiersin.org
Enlarged perivascular spaces (ePVS), visible on magnetic resonance imaging (MRI), are
associated with aortic pulse wave changes produced by arterial stiffening. However, the …

Brain enlarged perivascular spaces as imaging biomarkers of cerebrovascular disease: a clinical narrative review

S Ramaswamy, F Khasiyev… - Journal of the American …, 2022 - Am Heart Assoc
Perivascular spaces or Virchow‐Robin spaces form pathways along the subarachnoid
spaces that facilitate the effective clearance of brain metabolic by‐products through …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

Enlarged perivascular spaces and cognition: a meta-analysis of 5 population-based studies

S Hilal, CS Tan, HHH Adams, M Habes, V Mok… - Neurology, 2018 - AAN Enterprises
Objective To investigate the association of enlarged perivascular spaces (ePVS) with
cognition in elderly without dementia. Methods We included 5 studies from the Uniform …