Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

W Liu, Y Rong, J Wang, Z Zhou, X Ge, C Ji… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with
high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano …

Exosome-shuttled miR-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting AIM2/ASC/Caspase-1 signaling pathway mediated …

Z Zhou, C Li, T Bao, X Zhao, W Xiong, C Luo… - Journal of …, 2022 - liebertpub.com
Traumatic spinal cord injury (TSCI) is a devastating traumatic disease of the central nervous
system, which leads to refractory loss of motor and sensory function. So far, there is no …

miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

X Lai, Y Wang, X Wang, B Liu, L Rong - Stem cell research & therapy, 2022 - Springer
Background Acute spinal cord injury (SCI) is a devastating result of neurological trauma with
subsequent microenvironment dyshomeostasis that induces neurotoxic phenotype …

Exosomes derived from miR-544-modified mesenchymal stem cells promote recovery after spinal cord injury

C Li, X Li, B Zhao, C Wang - Archives of physiology and …, 2020 - Taylor & Francis
Recent evidence has demonstrated that exosomes derived from mesenchymal stem cells
(MSCs) may serve as a reservoir of miRNAs conferring protection from certain diseases …

[HTML][HTML] Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism

K Ma, H Xu, J Zhang, F Zhao, H Liang, H Sun… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) remains the most common cause of paralysis, and there are no
effective therapies for SCI patients. Neural stem cell (NSC)-derived exosomes can attenuate …

Exosomes derived from miR-133b-modified mesenchymal stem cells promote recovery after spinal cord injury

D Li, P Zhang, X Yao, H Li, H Shen, X Li… - Frontiers in …, 2018 - frontiersin.org
Dysregulation of microRNAs (miRNAs) has been found in injured spinal cords after spinal
cord injury (SCI). Previous studies have shown that miR-133b plays an important role in the …

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

D Jiang, F Gong, X Ge, C Lv, C Huang, S Feng… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor
dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an …

Rat bone mesenchymal stem cell‐derived exosomes loaded with miR‐494 promoting neurofilament regeneration and behavioral function recovery after spinal cord …

W Huang, M Lin, C Yang, F Wang… - Oxidative medicine …, 2021 - Wiley Online Library
Exosomes (Exo) exhibit numerous advantages (eg, good encapsulation, high targeting
efficiency, and easy to penetrate the blood‐brain barrier to the central nervous system) …

Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury

F Yuan, W Peng, Y Yang, J Xu, Y Liu, Y Xie… - Journal of …, 2023 - Springer
Background Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-
inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor …

Exosomes derived from miR-126-modified MSCs promote angiogenesis and neurogenesis and attenuate apoptosis after spinal cord injury in rats

JH Huang, Y Xu, XM Yin, FY Lin - Neuroscience, 2020 - Elsevier
Spinal cord injury (SCI) is a devastating neurological event that results in incomplete or
complete loss of voluntary motor and sensory function. Until recently, there has been no …