A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
[HTML][HTML] Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic
T Lencz, AK Malhotra - Molecular psychiatry, 2015 - nature.com
Abstract The Psychiatric Genomics Consortium–Schizophrenia Workgroup (PGC–SCZ) has
recently published a genomewide association study (GWAS) identifying> 100 genetic loci …
recently published a genomewide association study (GWAS) identifying> 100 genetic loci …
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Heritability analyses of genome-wide association study (GWAS) cohorts have yielded
important insights into complex disease architecture, and increasing sample sizes hold the …
important insights into complex disease architecture, and increasing sample sizes hold the …
Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective
Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …
discovery in schizophrenia; their findings have important implications not just for our …
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
Genome-wide association studies of schizophrenia: does bigger lead to better results?
SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …
mechanisms leading to manifestation of the disease. New and more effective treatments for …
[HTML][HTML] Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …
[HTML][HTML] Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …