Ulcerative colitis (UC) is a chronic intestinal inflammatory disease. Necroptosis plays an
important role in the pathogenesis of UC. Celastrol, a triterpene from the root bark of the …

Celastrol, also named as tripterine, is a pharmacologically active ingredient extracted from
the root of traditional Chinese herb Tripterygium wilfordii Hook F with potent anti …

Therapeutic agents that block the nuclear factor-kappa B (NF-κB) pathway might be
beneficial for incurable inflammatory diseases, such as ulcerative colitis. Here, we …

Hesperetin, a flavonoid from citrus fruits, possess various pharmacological properties,
including anti-inflammatory, anti-oxidative, anti-tumor potentials. However, the role and its …

Background Celastrol had been proved effective in the treatment for IBD, probably with the
modulation of oxidative stress, inflammatory cytokines and intestinal homeostasis. This study …

Celastrol, a triterpene isolated from the root of traditional Chinese medicine Thunder of God
Vine, possesses anti-cancer and anti-inflammatory activity to treat rheumatoid disease or as …

Background Wedelolactone, main active constituent of Wedelia calendulace and Eclipta
alba plants which has been traditionally used to treat various chronic inflammatory …

It has been reported that the ethanol extract of Wedelia chinensis attenuates murine colitis.
Wedelolactone (WEL), a coumestane-type compound with many pharmacological activities …

Background: M10 is a derivative of Myricetin by adding a hydrophilic glycosylation group.
Our previous study revealed that M10 by oral administration prevented colitis-associated …

Sepsis, a life-threatening syndrome with uncontrolled inflammatory response, causes high
morbidity and mortality worldwide. Currently, satisfactory treatments on sepsis are still …