The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors …

Objective—Loss-of-function mutations in human hepatocyte nuclear factor 4α (HNF4α) are
associated with maturity-onset diabetes of the young and lipid disorders. However, the …

Hepatocyte nuclear factor 4α (HNF4α) regulates genes involved in lipid and bile acid
synthesis, gluconeogenesis, amino acid metabolism, and blood coagulation. In addition to …

The winged helix transcription factor, hepatocyte nuclear factor-3β (HNF-3β), mediates the
hepatocyte-specific transcription of numerous genes important for liver function. However …

Hepatocyte nuclear factor-4α (HNF4α) is known as the master regulator of hepatocyte
differentiation. Recent studies indicate that HNF4α may inhibit hepatocyte proliferation via …

and function of the adult liver. Gene expression is primarily controlled through the action of
transcription factors that respond to environmental, autocrine, or paracrine signals. Studies …

Hepatocyte nuclear factor 4α (HNF-4α)(nuclear receptor 2A1) is an essential regulator of
hepatocyte differentiation and function. Genetic and molecular evidence suggests that the …

The hepatocyte nuclear factor 3α (HNF-3α),-3β, and-3γ proteins share homology in the
winged-helix/fork head DNA binding domain and mediate hepatocyte-enriched transcription …

HNF-4α is a transcription factor of the nuclear hormone receptor family that is expressed in
the hepatic diverticulum at the onset of liver development. Mouse embryos lacking HNF-4α …

The hepatocyte nuclear factor (HNF) 4α gene possesses two promoters, proximal P1 and
distal P2, whose use results in HNF4α1 and HNF4α7 transcripts, respectively. Both isoforms …