Apoptosis: Giving Phosphatidylserine Recognition an Assist — with a Twist Dispatch Page
1 Apoptosis: Giving Phosphatidylserine Recognition an Assist — with a Twist Valerie A …

One of the hallmarks of cell death is the cell surface–expression of phosphatidylserine.
Expression of phosphatidylserine at the cell surface can be measured in vitro with the …

Identification and clearance of apoptotic cells prevents the release of harmful cell contents
thereby suppressing inflammation and autoimmune reactions. Highly conserved annexins …

Healthy cells exhibit an asymmetric plasma membrane with phosphatidylserine (PS) located
on the cytoplasmic leaflet of the plasma membrane bilayer. Annexin A5-FITC, a PS binding …

Apoptosis and subsequent clearance of apoptotic cells are important for the prevention of
diseases. Therefore, it is essential to understand the mechanisms underlying the biology of …

Exposure of the aminophospholipid phosphatidylserine at the outer leaflet of the plasma
membrane by apoptotic cells can trigger phagocytic removal of these dying cells. This …

Phosphatidylserine (PS) exposure on the external leaflet of the plasma membrane is widely
observed during apoptosis and forms the basis for the annexin V binding assay to detect …

Apoptosis is a mode of cell death that is accompanied by specific alterations to the plasma
membrane that promote the recognition and engulfment of these cells by phagocytes …

When cells undergo apoptosis, or programmed cell death, they expose phosphatidylserine
(PS) on their surface. Macrophages that efficiently phagocytose apoptotic cells also express …

One of the earliest events in programmed cell death is the externalization of
phosphatidylserine, a membrane phospholipid normally restricted to the inner leaflet of the …