Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …

Dependency on tumor oxygenation is one of the major features of radiation therapy and this
has led many radiation biologists and oncologists to focus on tumor hypoxia. The first …

A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts
radiotherapy. As a result, there has been longstanding active research into novel methods of …

Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and
oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and …

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor
(HIF-1) creates a microenvironment and cancer cells' intrinsic signaling networks conferring …

Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its
critical role in radio-and chemoresistance and its significance as an adverse prognostic …

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Transcriptional activity of HIF-1 (hypoxia-inducible factor-1) has been reported to be up-
regulated in solid tumors after ionizing radiation; however, the molecular mechanism …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …