Phenols and phenolic ethers are significant scaffolds recurring both in nature and among
approved small-molecule pharmaceuticals. This compendium presents the first …

Previous analyses have revealed that benzenoid rings are prevalent scaffolds in active
pharmaceutical ingredients (APIs). Here, we analyze the substitution patterns of benzenoid …

STRONGHOLDS FOR DRUG DISCOVERY Historically, natural products (NPs) have played
a key role in the development of chemotherapy, 1, 2 and to this very day numerous marketed …

Covering: 1981 to 2019 Natural products continue to play a major role in drug discovery,
with half of new chemical entities based structurally on a natural product. Herein, we report a …

Covering: up to 2021 The structural core of most small-molecule drugs is formed by a ring
system, often derived from natural products. However, despite the importance of natural …

Despite the recent decline of natural product discovery programs in the pharmaceutical
industry, approximately half of all new drug approvals still trace their structural origins to a …

Polyphenols are a large family of phytochemicals with great chemical diversity, known to be
bioactive compounds of foods, species, medicinal plants and nutraceuticals. These …

Covering: up to 2020 Natural products have a long history in drug discovery, with their
inherent biological activity often tailored by medicinal chemists to arrive at the final drug …

In the period 1970–2006, a total of 24 unique natural products were discovered that led to
an approved drug. We analyze these successful leads in terms of drug-like properties, and …

The paradigm of “drug-like-ness” dramatically altered the behavior of the medicinal
chemistry community for a long time. In recent years, scientists have empirically found a …