[HTML][HTML] Cellular sources of TSPO expression in healthy and diseased brain
E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
[HTML][HTML] Cellular sources and regional variations in the expression of the neuroinflammatory marker translocator protein (TSPO) in the normal brain
C Betlazar, M Harrison-Brown, RJ Middleton… - International Journal of …, 2018 - mdpi.com
The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …
[HTML][HTML] Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
ASC Ching, B Kuhnast, A Damont, D Roeda… - Insights into …, 2012 - Springer
Neuroinflammation is a process characterised by drastic changes in microglial morphology
and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria …
and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria …
The methodology of TSPO imaging with positron emission tomography
FE Turkheimer, G Rizzo, PS Bloomfield… - Biochemical Society …, 2015 - portlandpress.com
The 18-kDA translocator protein (TSPO) is consistently elevated in activated microglia of the
central nervous system (CNS) in response to a variety of insults as well as …
central nervous system (CNS) in response to a variety of insults as well as …
[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization
TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
[HTML][HTML] Astrocytic TSPO upregulation appears before microglial TSPO in Alzheimer's disease
BB Tournier, S Tsartsalis, K Ceyzériat… - Journal of …, 2020 - content.iospress.com
Background: In vivo PET/SPECT imaging of neuroinflammation is primarily based on the
estimation of the 18kDatranslocator-protein (TSPO). However, TSPO is expressed by …
estimation of the 18kDatranslocator-protein (TSPO). However, TSPO is expressed by …
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
E Nutma, JA Stephenson, RP Gorter, J de Bruin… - Brain, 2019 - academic.oup.com
The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding
BB Tournier, S Tsartsalis, K Ceyzériat… - Journal of Cerebral …, 2020 - journals.sagepub.com
Many studies have explored the role of TSPO (18 kDa translocator protein) as a marker of
neuroinflammation using single-photon emission computed tomography (SPECT) or …
neuroinflammation using single-photon emission computed tomography (SPECT) or …
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
M Cosenza‐Nashat, ML Zhao, HS Suh… - Neuropathology and …, 2009 - Wiley Online Library
Aims: Microglia are involved in neurodegeneration, are prime targets for anti‐inflammatory
therapy and are potential biomarkers of disease progression. For example, positron …
therapy and are potential biomarkers of disease progression. For example, positron …
[HTML][HTML] In vivo TSPO signal and neuroinflammation in Alzheimer's disease
In the last decade, positron emission tomography (PET) and single-photon emission
computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the …
computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the …