Background Recently, numerous studies have reported the interaction between senescence
and oxidative stress in cancer. However, there is a lack of a comprehensive understanding …

Significance Cellular growth arrest, associated with 'senescence', helps to safeguard against
the accumulation of DNA damage which is often recognized as the underlying mechanism of …

Therapy-induced senescent tumor cells have emerged as significant drivers of tumor
recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production …

Cellular senescence describes an irreversible growth arrest characterized by distinct
morphology, gene expression pattern, and secretory phenotype. The final or intermediate …

Metabolic disorders are considered the hallmarks of cancer and metabolic reprogramming is
emerging as a new strategy for cancer treatment. Exogenous and endogenous stressors can …

Cellular senescence has long been considered to act as a tumor suppressor or tumor
suppression mechanism and described as a phenomenon of irreversible cell cycle arrest …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

Senescence is a double-edged sword that can function in opposite directions. It is a
potential mechanism for a cell to avoid malignant transformation. However, senescence can …

The process of carcinogenesis and its progression involves an intricate interplay between a
number of signaling networks, metabolic pathways and the microenvironment. These …

Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …