BACKGROUND The trauma patient on direct oral anticoagulant (DOAC) therapy preinjury
presents a challenge in trauma and acute care surgery. Our understanding of these patients …

Background Warfarin is associated with poor outcomes after trauma, an effect correlated
with elevations in the international normalized ratio (INR). In contrast, the novel oral …

Background The ability to assess the hemostatic effect of the direct oral anticoagulant
(DOACs) may be valuable in clinical situations such as bleeding or thrombosis, before …

Non vitamin K oral anticoagulants (NOACs) do not require regular monitoring but
information about their pharmacodynamic effect may be importantin situations like trauma …

Background With the widespread use of direct oral anticoagulants (DOACs), there is an
urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and …

Background The anticoagulated trauma patient presents a particular challenge to the critical
care physician. Our understanding of these patients is defined and extrapolated by …

In urgent clinical situations, such as trauma, urgent surgery or before thrombolysis, rapid
quantification of direct oral anticoagulant plasma drug levels is warranted. Using the …

Background Direct-acting oral anticoagulants (DOACs) do not require monitoring.
Measurement of DOAC effect would be useful in the event of bleeding, trauma, and …

Specific antagonists have been developed for the reversal of direct oral anticoagulants
(DOAC). We investigated the impact of these reversal agents on the plasma concentration …

BACKGROUND Viscoelastic coagulation testing is increasingly used to diagnose trauma-
induced coagulopathy. Two fully automated analysers, TEG 6s and ROTEM Sigma, were …