Engineering functional cardiac tissues remains an ongoing significant challenge due to the
complexity of the native environment. However, our growing understanding of key …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Myocardial ischaemia is one of the leading dead causes worldwide. Although animal
experiments have historically provided a wealth of information, animal models are time and …

The advances in biotechnology, biomechanics, and biomaterials can be used to develop
organ models that aim to accurately emulate their natural counterparts. Heart disease, one …

Modeling integrated human physiology in vitro is a formidable task not yet achieved with any
of the existing cell/tissue systems. However, tissue engineering is becoming increasingly …

The microenvironment of myocardium plays an important role in the fate and function of
cardiomyocytes (CMs). Cardiovascular tissue engineering strategies commonly utilize stem …

Through the use of stem cell-derived cardiac myocytes, tissue-engineered human
myocardial constructs are poised for modeling normal and diseased physiology of the heart …

Modeling integrated human physiology in vitro is a formidable task not yet achieved with any
of the existing cell/tissue systems. However, tissue engineering is becoming increasingly …

Highlights•A concise historical perspective on the evolution of cardiac tissue
engineering.•Reveal the potential of bioengineering for studying cellular …

There is need for a reliable in vitro system that can accurately replicate the cardiac
physiological environment for drug testing. The limited availability of human heart tissue …