Background Neuroinflammation is involved in the pathophysiology of Alzheimer's disease
(AD), including immune-linked genetic variants and molecular pathways, microglia and …

Defining the mechanisms involved in the aetiology of Alzheimer's disease from genome-
wide association studies alone is challenging since Alzheimer's disease is polygenic and …

The occurrence of immune disease comorbidities in Alzheimer's disease (AD) has been
observed in both epidemiological and molecular studies, suggesting a neuroinflammatory …

Microglia, the macrophages of the brain, are vital for brain homeostasis and have been
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …

Objectives We assessed the current genetic evidence for the involvement of various cell
types and tissue types in the etiology of neurodegenerative diseases, especially in relation …

The existing large-scale genome-wide association studies (GWAS) datasets provide strong
support for investigating the mechanisms of Alzheimer's disease (AD) by applying multiple …

Alzheimer's disease (AD) is the most common cause of dementia. Although genome-wide
association study (GWAS) have reported hundreds of single-nucleotide polymorphisms …

Alzheimer's disease (AD) is the most frequent neurodegenerative disease with more than 35
million people affected worldwide, and no curative treatment currently available. AD is highly …

The occurrence of immune disease comorbidities in Alzheimer's disease (AD) has been
observed in both epidemiological and molecular studies, suggesting a neuroinflammatory …

Introduction Genome-wide association studies (GWAS) have successfully identified multiple
independent genetic loci that harbour variants associated with Alzheimer's disease, but the …