A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent
and-independent stress responses. A variety of abnormal metabolic conditions, cytotoxic …

Cell proliferation and cell growth are two tightly linked processes, as the proliferation
program cannot be executed without proper accumulation of cell mass, otherwise …

The oncoprotein MDM2 is both the transcriptional target and the predominant antagonist of
the tumor suppressor p53. MDM2 inhibits the functions of p53 via a negative feedback loop …

Inherently disparate cell growth and division, which are intimately coupled through a
delicate network of intracellular and extracellular signaling, require ribosomal biogenesis. A …

The dynamic processes of cell growth and cell division remain under constant surveillance.
As one of the primary 'gatekeepers' of the cell, p53 has a major role in sensing a variety of …

Ribosomal biogenesis is tightly associated with cellular activities, such as growth,
proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

The nucleolus is the site of ribosome biogenesis, a complex process that requires the
coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that …

Ribosomal proteins (RPs) have gained much attention for their extraribosomal functions
particularly with respect to p53 regulation. To date, about fourteen RPs have shown to bind …