Biodegradable PLGA85/15 nanoparticles as a delivery vehicle for Chlamydia trachomatis recombinant MOMP-187 peptide

MA Taha, SR Singh, VA Dennis - Nanotechnology, 2012 - iopscience.iop.org
Abstract Development of a Chlamydia trachomatis vaccine has been a formidable task partly
because of an ineffective delivery system. Our laboratory has generated a recombinant …

Chlamydia trachomatis recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a …

SJ Fairley, SR Singh, AN Yilma, AB Waffo… - International journal …, 2013 - Taylor & Francis
We recently demonstrated by in vitro experiments that PLGA (poly D, L-lactide-co-glycolide)
potentiates T helper 1 (Th1) immune responses induced by a peptide derived from the …

Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Chlamydia muridarum Genital …

R Sahu, S Dixit, R Verma, SA Duncan, L Smith… - Frontiers in …, 2021 - frontiersin.org
Recently we reported the immune-potentiating capacity of a Chlamydia nanovaccine (PLGA-
rMOMP) comprising rMOMP (recombinant major outer membrane protein) encapsulated in …

Formulation, characterization, and expression of a recombinant MOMP Chlamydia trachomatis DNA vaccine encapsulated in chitosan nanoparticles

CD Cambridge, SR Singh, AB Waffo… - International journal …, 2013 - Taylor & Francis
Chlamydia trachomatis is a bacterial sexually transmitted infection affecting millions of
people worldwide. Previous vaccination attempts have employed the recombinant major …

Poly (lactic acid)–poly (ethylene glycol) nanoparticles provide sustained delivery of a Chlamydia trachomatis recombinant MOMP peptide and potentiate systemic …

S Dixit, SR Singh, AN Yilma, RD Agee II, M Taha… - … , Biology and Medicine, 2014 - Elsevier
PLA–PEG [poly (lactic acid)–poly (ethylene glycol)], a biodegradable copolymer, is
underexploited for vaccine delivery although it exhibits enhanced biocompatibility and slow …

A nanovaccine formulation of Chlamydia recombinant MOMP encapsulated in PLGA 85: 15 nanoparticles augments CD4+ effector (CD44high CD62Llow) and …

R Sahu, S Dixit, R Verma, SA Duncan, MT Coats… - … , Biology and Medicine, 2020 - Elsevier
Vaccine developmental strategies are utilizing antigens encapsulated in biodegradable
polymeric nanoparticles. Here, we developed a Chlamydia nanovaccine (PLGA-rMOMP) by …

The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects …

R Verma, R Sahu, S Dixit, SA Duncan… - Frontiers in …, 2018 - frontiersin.org
Recently, we reported that our PPM chlamydial nanovaccine [a biodegradable co-polymeric
PLA-PEG (poly (lactic acid)-poly (ethylene glycol))-encapsulated M278 peptide (derived …

Caveolin-mediated endocytosis of the Chlamydia M278 outer membrane peptide encapsulated in poly (lactic acid)-Poly (ethylene glycol) nanoparticles by mouse …

S Dixit, R Sahu, R Verma, S Duncan… - Biomaterials, 2018 - Elsevier
We previously developed a Chlamydia trachomatis nanovaccine (PPM) by encapsulating a
chlamydial M278 peptide within poly (lactic acid)-poly (ethylene glycol) biodegradable …

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles

R Sahu, R Verma, S Dixit, JU Igietseme… - Expert review of …, 2018 - Taylor & Francis
Introduction: There is a persisting global burden and considerable public health challenge
by the plethora of ocular, genital and respiratory diseases caused by members of the Gram …

Chlamydia trachomatis: quest for an eye-opening vaccine breakthrough

VP Chavda, A Pandya, E Kypreos… - Expert Review of …, 2022 - Taylor & Francis
Introduction Chlamydia trachomatis, commonly referred to as chlamydia (a bacterium), is a
common sexually transmitted infection, and if attended to early, it can be treatable. However …