The half-life of a drug is most commonly defined as the time taken for the plasma or blood
level of the drug to fall by half. Elimination half-life, pharmacologic half-life, and biologic half …

The half-life of a drug is the time taken for the blood level of the drug to fall by half, provided
that no more doses of the drug are administered in the intervening period. Many …

Half-life in the context of medical science typically refers to the elimination half-life. The
definition of elimination half-life is the length of time required for the concentration of a …

This chapter summarizes the pharmacokinetic principles that are essential in everyday
clinical practice: Whenever initiating a dosage, changing a dosage, or upon cessation of a …

The application of pharmacokinetic principles to the administration of psychotropic
medications provides a rational approach to understanding factors influencing the time …

The half-life of a drug, which expresses a change in concentration in units of time, is perhaps
the most easily understood pharmacokinetic parameter and provides a succinct description …

In pharmacokinetics, the apparent or effective half-life of a drug may be a manifestation of
the kinetics of elimination, the kinetics of absorption, the kinetics of disappearance from the …

T he concept of an “effective half-life” for drug accumulation was initially posited by Kwan
and Duggan in 19771 and was formally examined in 1984.2 In principle, an effective half-life …

ABSTRACT A drug's half-life of elimination from plasma or serum has long been considered
a familiar and important pharmacologic property. In fact, elimination half-life has limitations …

Completely updated with newly approved drugs and indications and new formulations, this
pocket-sized handbook is a one-stop quick-reference guide to prescribing psychotropic …