Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4 …
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …
Comprehensive high-resolution mass spectrometric analysis of DNA phosphate adducts formed by the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
Methyl DNA phosphate adduct formation in rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
powerful lung carcinogen in animal models and is considered a causative factor for lung …
powerful lung carcinogen in animal models and is considered a causative factor for lung …
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine
The tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4 …
The tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
is metabolically converted to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a …
is metabolically converted to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in …
JF Cloutier, R Drouin, M Weinfeld, TR O'Connor… - Journal of Molecular …, 2001 - Elsevier
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl …
ME Staretz, PG Foiles, LM Miglietta, SS Hecht - Cancer research, 1997 - AACR
Abstract The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK), selectively induces lung tumors in F344 rats. NNK is metabolically activated to …
(NNK), selectively induces lung tumors in F344 rats. NNK is metabolically activated to …
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its …
P Upadhyaya, S Kalscheuer, JB Hochalter… - Chemical research in …, 2008 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
P Upadhyaya, SJ Sturla, N Tretyakova… - Chemical research in …, 2003 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of the tobacco specific
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …