The FERM domain containing protein Kindlin-3 has been recognized as a major regulator of
integrin function in hematopoietic cells, but its role in neoplasia is totally unknown. We have …

Abstract Background Kindlin-1,− 2, and− 3 are the three members of the Kindlin family. They
are best known as regulators of integrin functions, contributing to fundamental biological …

Abstract Kindlins are 4.1-ezrin-ridixin-moesin (FERM) domain containing proteins. There are
three kindlins in mammals, which share high sequence identity. Kindlin-1 is expressed …

Integrin activation is crucial for numerous cellular responses, including cell adhesion,
migration, and survival. Recent studies in mice have specifically emphasized the vital role of …

Studies of isolated cells, mice, and humans have demonstrated the vital role of the FERM
domain protein kindlin-3 in integrin activation in certain hematopoietic and non …

Abstract Kindlin-3 (FERMT-3) is known to be central in hemostasis and thrombosis control
and its deficiency disrupts platelet aggregation and causes Leukocyte Adhesion Deficiency …

Kindlin-2, a widely distributed cytoskeletal protein, has been implicated in integrin activation,
and its absence is embryonically lethal in mice and causes severe developmental defects in …

Kindlins are a small family of 4.1-ezrin-radixin-moesin (FERM)-containing cytoplasmic
proteins. Kindlin-3 is expressed in platelets, hematopoietic cells, and endothelial cells …

Background Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator
of integrin functions and is associated with Kindler syndrome, a genetic disorder …

The Kindlins are FERM domain proteins comprising three members (Kindlin-1,-2 and-3)
which are evolutionarily conserved. Kindlins bind with β-integrin cytoplasmic tails and …