Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

Background: Several early phase studies have demonstrated that psilocybin-assisted
therapy has rapid-acting and persisting antidepressant effects from just one or two doses …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Background Previous studies have shown that psilocybin has antidepressant effects. In the
current study, we aim to explore the dose effects of psilocybin on primary (major depression …

Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …

The aim of this review was to determine the effect of psilocybin on depressive symptoms in
patients diagnosed with life-threatening illnesses or major depressive disorder. Systematic …

Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

Background Psilocybin may have antidepressant properties, but direct comparisons
between psilocybin and established treatments for depression are lacking. Methods In a …

Psilocybin is increasingly studied for its antidepressant effect, but its optimal dosage for
depression remains unclear. We conducted a systematic review and a dose-response meta …

Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …