Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare

KR Chng, ASL Tay, C Li, AHQ Ng, J Wang, BK Suri… - Nature …, 2016 - nature.com
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases,
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

HH Kong, J Oh, C Deming, S Conlan, EA Grice… - Genome …, 2012 - genome.cshlp.org
Atopic dermatitis (AD) has long been associated with Staphylococcus aureus skin
colonization or infection and is typically managed with regimens that include antimicrobial …

Microbe-host interplay in atopic dermatitis and psoriasis

N Fyhrquist, G Muirhead, S Prast-Nielsen… - Nature …, 2019 - nature.com
Despite recent advances in understanding microbial diversity in skin homeostasis, the
relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we …

Integrating cultivation and metagenomics for a multi-kingdom view of skin microbiome diversity and functions

S Saheb Kashaf, DM Proctor, C Deming, P Saary… - Nature …, 2022 - nature.com
Human skin functions as a physical barrier to foreign pathogen invasion and houses
numerous commensals. Shifts in the human skin microbiome have been associated with …

[HTML][HTML] Research techniques made simple: profiling the skin microbiota

MD Grogan, C Bartow-McKenney, L Flowers… - Journal of Investigative …, 2019 - Elsevier
Skin is colonized by microbial communities (microbiota) that participate in immune
homeostasis, development and maintenance of barrier function, and protection from …

Evolving approaches to profiling the microbiome in skin disease

Y Chen, R Knight, RL Gallo - Frontiers in Immunology, 2023 - frontiersin.org
Despite its harsh and dry environment, human skin is home to diverse microbes, including
bacteria, fungi, viruses, and microscopic mites. These microbes form communities that may …

The intersection of microbiome and host at the skin interface: genomic-and metagenomic-based insights

EA Grice - Genome research, 2015 - genome.cshlp.org
The past two decades have been marked by a surge in research to understand the microbial
communities that live in association with the human body, in part stimulated by affordable …

Microbiome dynamics of human epidermis following skin barrier disruption

PLJM Zeeuwen, J Boekhorst, EH van den Bogaard… - Genome biology, 2012 - Springer
Background Recent advances in sequencing technologies have enabled metagenomic
analyses of many human body sites. Several studies have catalogued the composition of …

[HTML][HTML] Skin microbiome surveys are strongly influenced by experimental design

JS Meisel, GD Hannigan, AS Tyldsley… - Journal of Investigative …, 2016 - Elsevier
Culture-independent studies to characterize skin microbiota are increasingly common, due
in part to affordable and accessible sequencing and analysis platforms. Compared to culture …

Biogeography and individuality shape function in the human skin metagenome

J Oh, AL Byrd, C Deming, S Conlan, HH Kong… - Nature, 2014 - nature.com
The varied topography of human skin offers a unique opportunity to study how the body's
microenvironments influence the functional and taxonomic composition of microbial …