A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Identification of thyroid disrupting chemicals (TDCs), one of the most studied types of
endocrine disruptors (EDs), is required according to EU regulations on industrial chemicals …

ERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded
research and innovation action, that aims to break down the wall between mammalian and …

Background Assessing adverse effects from environmental chemical exposure is integral to
public health policies. Toxicology assays identifying early biological changes from chemical …

The thyroid hormone (TH) system is involved in several important physiological processes,
including regulation of energy metabolism, growth and differentiation, development and …

Background: The US EPA's Endocrine Disruptor Screening Program (EDSP) screens and
tests environmental chemicals for potential effects in estrogen, androgen, and thyroid …

The adverse outcome pathway (AOP) framework can be used to help support the
development of alternative testing strategies aimed at predicting adverse outcomes caused …

Endocrine disruption (ED) can trigger far-reaching effects on environmental populations,
justifying a refusal of market approval for chemicals with ED properties. For the hazard …

Globally, regulatory authorities grapple with the challenge of assessing the hazards and
risks to human and ecosystem health that may result from exposure to chemicals that disrupt …