Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1
(PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative …

Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in
cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include …

Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid,
palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it …

Abstract Background Neuronal ceroid lipofuscinoses (NCLs) are collectively the most
common type of recessively inherited childhood encephalopathies. The most severe form of …

Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal
Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease. During recent …

Infantile-onset Neuronal Ceroid Lipofuscinosis (INCL) is a severe pediatric
neurodegenerative disorder produced by mutations in the gene encoding palmitoyl-protein …

Neuronal ceroid lipofuscinoses represent the most common childhood neurodegenerative
storage disorders. Infantile neuronal ceroid lipofuscinosis (INCL) is caused by palmitoyl …

Abstract Palmitoyl protein thioesterase 1 (PPT1) is a depalmitoylating enzyme whose
deficiency leads to infantile neuronal ceroid lipofuscinosis. The disease is characterized by …

Protein palmitoylation is the only reversible post-translational lipid modification.
Palmitoylation is held in delicate balance by depalmitoylation to precisely regulate protein …

Kainic acid (KA)-induced experimental epilepsy, a model of excitotoxicity, leads to selective
neuronal death and synaptic restructuring. We used this model to investigate the effects of …