Encapsulation of Gold-Based Anticancer Agents in Protease-Degradable Peptide Nanofilaments Enhances Their Potency
Y Marciano, V Del Solar, N Nayeem… - Journal of the …, 2022 - ACS Publications
We investigated the use of amphiphilic, protease-cleavable peptides as encapsulation
moieties for hydrophobic metallodrugs, in order to enhance their bioavailability and …
moieties for hydrophobic metallodrugs, in order to enhance their bioavailability and …
N-Acetylation of Biodegradable Supramolecular Peptide Nanofilaments Selectively Enhances Their Proteolytic Stability for Targeted Delivery of Gold-Based …
Peptide materials are promising for various biomedical applications; however, a significant
concern is their lack of stability and rapid degradation in vivo due to non-specific proteolysis …
concern is their lack of stability and rapid degradation in vivo due to non-specific proteolysis …
[HTML][HTML] A general-purpose nanohybrid fabricated by polymeric Au (I)-peptide precursor to wake the function of peptide therapeutics
Peptide-derived nanocomposites have been exhibiting fascinating biological advantages,
including but not limited to excellent biocompatibility, biological degradation, high …
including but not limited to excellent biocompatibility, biological degradation, high …
Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer
DJ Toft, TJ Moyer, SM Standley, Y Ruff, A Ugolkov… - ACS …, 2012 - ACS Publications
Self-assembled peptide amphiphiles (PAs) consisting of hydrophobic, hydvrogen-bonding,
and charged hydrophilic domains form cylindrical nanofibers in physiological conditions and …
and charged hydrophilic domains form cylindrical nanofibers in physiological conditions and …
Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells
Abstract Background Peptide-drug-conjugates (PDCs) are being developed as an effective
strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges …
strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges …
Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme‐Induced Local Retention Properties
V Bellat, R Ting, TL Southard, L Vahdat… - Advanced functional …, 2018 - Wiley Online Library
An effective tumoral delivery system should show minimal removal by the reticuloendothelial
system (RES), promote tumor uptake and penetration, and minimize on‐site clearance. This …
system (RES), promote tumor uptake and penetration, and minimize on‐site clearance. This …
Tumor targeting by peptide-decorated gold nanoparticles
B Albertini, V Mathieu, N Iraci… - Molecular …, 2019 - ACS Publications
Cancer remains one of the most important challenges in biomedical sciences.
Chemotherapeutic agents are very potent molecules that exhibit a significant level of toxicity …
Chemotherapeutic agents are very potent molecules that exhibit a significant level of toxicity …
Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility
P Wadhwani, N Heidenreich, B Podeyn, J Bürck… - Biomaterials …, 2017 - pubs.rsc.org
Peptide-coated nanoparticles are valuable tools for diverse biological applications, such as
drug delivery, molecular recognition, and antimicrobial action. The functionalization of pre …
drug delivery, molecular recognition, and antimicrobial action. The functionalization of pre …
[HTML][HTML] A facile route to tailoring peptide-stabilized gold nanoparticles using glutathione as a synthon
RH Wu, TP Nguyen, GW Marquart, TJ Miesen, T Mau… - Molecules, 2014 - mdpi.com
The preparation of gold nanoparticles (AuNPs) of high purity and stability remains a major
challenge for biological applications. This paper reports a simple synthetic strategy to …
challenge for biological applications. This paper reports a simple synthetic strategy to …
Synthesis and organization of gold-peptide nanoparticles for catalytic activities
A significant development in the synthesis strategies of metal-peptide composites and their
applications in biomedical and bio-catalysis has been reported. However, the random …
applications in biomedical and bio-catalysis has been reported. However, the random …
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