Encapsulation of Gold-Based Anticancer Agents in Protease-Degradable Peptide Nanofilaments Enhances Their Potency

Y Marciano, V Del Solar, N Nayeem… - Journal of the …, 2022 - ACS Publications
We investigated the use of amphiphilic, protease-cleavable peptides as encapsulation
moieties for hydrophobic metallodrugs, in order to enhance their bioavailability and …

N-Acetylation of Biodegradable Supramolecular Peptide Nanofilaments Selectively Enhances Their Proteolytic Stability for Targeted Delivery of Gold-Based …

Y Marciano, N Nayeem, D Dave, RV Ulijn… - … biomaterials science & …, 2023 - ACS Publications
Peptide materials are promising for various biomedical applications; however, a significant
concern is their lack of stability and rapid degradation in vivo due to non-specific proteolysis …

[HTML][HTML] A general-purpose nanohybrid fabricated by polymeric Au (I)-peptide precursor to wake the function of peptide therapeutics

J Yan, F Ji, S Yan, W You, F Ma, F Li, Y Huang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Peptide-derived nanocomposites have been exhibiting fascinating biological advantages,
including but not limited to excellent biocompatibility, biological degradation, high …

Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer

DJ Toft, TJ Moyer, SM Standley, Y Ruff, A Ugolkov… - ACS …, 2012 - ACS Publications
Self-assembled peptide amphiphiles (PAs) consisting of hydrophobic, hydvrogen-bonding,
and charged hydrophilic domains form cylindrical nanofibers in physiological conditions and …

Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells

K Kalimuthu, BC Lubin, A Bazylevich… - Journal of …, 2018 - Springer
Abstract Background Peptide-drug-conjugates (PDCs) are being developed as an effective
strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges …

Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme‐Induced Local Retention Properties

V Bellat, R Ting, TL Southard, L Vahdat… - Advanced functional …, 2018 - Wiley Online Library
An effective tumoral delivery system should show minimal removal by the reticuloendothelial
system (RES), promote tumor uptake and penetration, and minimize on‐site clearance. This …

Tumor targeting by peptide-decorated gold nanoparticles

B Albertini, V Mathieu, N Iraci… - Molecular …, 2019 - ACS Publications
Cancer remains one of the most important challenges in biomedical sciences.
Chemotherapeutic agents are very potent molecules that exhibit a significant level of toxicity …

Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility

P Wadhwani, N Heidenreich, B Podeyn, J Bürck… - Biomaterials …, 2017 - pubs.rsc.org
Peptide-coated nanoparticles are valuable tools for diverse biological applications, such as
drug delivery, molecular recognition, and antimicrobial action. The functionalization of pre …

[HTML][HTML] A facile route to tailoring peptide-stabilized gold nanoparticles using glutathione as a synthon

RH Wu, TP Nguyen, GW Marquart, TJ Miesen, T Mau… - Molecules, 2014 - mdpi.com
The preparation of gold nanoparticles (AuNPs) of high purity and stability remains a major
challenge for biological applications. This paper reports a simple synthetic strategy to …

Synthesis and organization of gold-peptide nanoparticles for catalytic activities

M Abbas, HH Susapto, CAE Hauser - ACS omega, 2022 - ACS Publications
A significant development in the synthesis strategies of metal-peptide composites and their
applications in biomedical and bio-catalysis has been reported. However, the random …