Stability is one of the most important properties of drug candidates. Instable compounds can
lead to false positive high‐throughput screening (HTS) hits, incorrect bioassay results …

Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies,
and Best Practices | SpringerLink Skip to main content Advertisement SpringerLink Log in …

Solution stability of drug candidates in plasma, gastrointestinal fluids and bioassays is
important in order to achieve low clearance, good oral bioavailability and have robust SAR …

Pharmaceutical development is mostly focused on the research leading to approval of a new
and viable active substance. However, there is a number of old generation compounds that …

Screening of solution stability provides an early alert on potential liabilities of drug
candidates so that strategies can be developed to overcome the challenges. A fully …

Plasma stability plays an important role in drug discovery and development. Unstable
compounds tend to have rapid clearance and short half-life, resulting in poor in vivo …

Stability is one of the basic parameters, along with accuracy, precision, selectivity, and
sensitivity, for bioanalytic method validation in nonhuman and clinical pharmacology …

There has been significant growth in the use of modeling tools to accelerate development
and enhance pharmaceutical quality. Among these are empirical and semi-empirical …

Metabolic stability plays an important role in the success of drug candidates. First-pass
metabolism is one of the major causes of poor oral bioavailability and short half-life …

Stability testing is an essential part of pharmaceutical development program and is required
by regulatory agencies for establishing and sustaining the high quality products. The …