This study sheds light on a ground-breaking biochemical mechanotransduction pathway
and reveals how Piezo1 channels orchestrate cell migration. We observed an increased cell …

Actin polymerization and assembly into stress fibers (SFs) is central to many cellular
processes. However, how SFs form in response to the mechanical interaction of cells with …

The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors,
yet the link between it and the ubiquitously expressed mechanosensitive ion channel …

Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as
PIEZO1 are critical in mechanotransduction processes that influence cell differentiation …

Macropinocytosis is a type of endocytosis accompanied by actin rearrangement-driven
membrane deformation, such as lamellipodia formation and membrane ruffling, followed by …

Lamellipodial protrusion and directional migration of carcinoma cells towards
chemoattractants, such as epidermal growth factor (EGF), depend upon the spatial and …

Cofilin is a key player in actin dynamics during cell migration. Its activity is regulated by (de)
phosphorylation, pH, and binding to phosphatidylinositol-4, 5-bisphosphate [PI (4, 5) P2] …

Membrane protrusions, like lamellipodia, and cell movement are dependent on actin
dynamics, which are regulated by a variety of actin-binding proteins acting cooperatively to …

Microgeometry profoundly impacts cellular behaviors, yet the link between it and the
ubiquitously expressed mechanosensitive ion channel PIEZO1 remains enigmatic. We …

Piezo channels transduce mechanical stimuli into electrical and chemical signals to
powerfully influence development, tissue homeostasis, and regeneration. Studies on Piezo1 …