Microglial activation plays a central role in poststroke inflammation and causes secondary
neuronal damage; however, it also contributes in debris clearance and chronic recovery …

Microglial activation is a key element in initiating and perpetuating inflammatory responses
to stroke. Interferon regulatory factor 5 (IRF 5) and IRF 4 signaling have been found critical in …

Innate immune signaling is important in the pathophysiology of ischemia/reperfusion (stroke)-
induced injury and recovery. Several lines of evidence support a central role for microglia in …

Inflammation has a pivotal role in the pathogenesis of ischemic stroke, and recent studies
posit that inflammation acts as a double‐edged sword, not only detrimentally augmenting …

Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Background Microglia are the principal cells involved in the innate immune response in the
CNS. Activated microglia produce a number of proinflammatory cytokines implicated in …

Background Subtle adjustment of the activation status of CNS resident microglia and
peripheral macrophages, to promote their neuroprotective and neuroregenerative functions …

Recent epidemiological studies have identified interferon regulatory factor 8 (IRF8) as a
susceptibility factor for multiple sclerosis (MS). However, how IRF8 influences the …

After ischemic stroke, various damage-associated molecules are released from the ischemic
core and diffuse to the ischemic penumbra, activating microglia and promoting …

Ischemic stroke is one of the most common causes of death and disability worldwide.
Neuroinflammation is a major pathological event involved in the process of ischemic injury …