When searching for the ideal molecule to fill a particular functional role (for example, a
medicine), the difference between success and failure can often come down to a single …

Direct molecular editing of heteroarene carbon–hydrogen (C–H) bonds through consecutive
selective C–H functionalization has the potential to grant rapid access into diverse chemical …

Synthetic chemistry aims to build up molecular complexity from simple feedstocks. However,
the ability to exert precise changes that manipulate the connectivity of the molecular …

Deconstructive functionalization involves carbon–carbon (C–C) bond cleavage followed by
bond construction on one or more of the constituent carbons. For example, ozonolysis and …

Skeletal editing is a straightforward synthetic strategy for precise substitution or
rearrangement of atoms in core ring structures of complex molecules; it enables quick …

Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen
functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead …

Molecular diversity by design | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Abstract Carbon–hydrogen (C–H) and carbon–carbon (C–C) bonds are the main
constituents of organic matter. Recent advances in C–H functionalization technology have …

Carbon has the unique ability to bind four atoms and form stable tetravalent structures that
are prevalent in nature. The lack of one or two valences leads to a set of species …

Most functional groups, especially those consisting of the abundant elements of organic
matter—carbon, nitrogen and oxygen—have been extensively studied and only very few …