Acute respiratory distress syndrome is a multifactorial lung injury that continues to be
associated with high levels of morbidity and mortality. Mechanical ventilation, although …

Despite the recognition of its iatrogenic potential, mechanical ventilation remains the
mainstay of respiratory support for patients with acute respiratory distress syndrome (ARDS) …

Gentle lung ventilation must be standard practice. Because stress and strain are the triggers
of ventilator-induced lung injury, their clinical equivalents should be measured …

Rationale: Mortality in acute respiratory distress syndrome (ARDS) has decreased after the
adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower …

Acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure burden by
high hospital mortality. No specific pharmacologic treatment is currently available and its …

The main supportive therapy in acute respiratory distress syndrome patients is mechanical
ventilation. As with any therapy, mechanical ventilation has side-effects, and may induce …

Mechanical ventilation is a life-support system used to maintain adequate lung function in
patients who are critically ill or undergoing general anesthesia. The benefits and harms of …

Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give
rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory …

The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS)
arise from two main causes: unphysiological increases of transpulmonary pressure and …

Rationale: Lung injury caused by a ventilator results from nonphysiologic lung stress
(transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio) …