Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach

DL Mayfield, NJ Cronin, GA Lichtwark - Biomechanics and Modeling in …, 2023 - Springer
Age-related alterations of skeletal muscle are numerous and present inconsistently, and the
effect of their interaction on contractile performance can be nonintuitive. Hill-type muscle …

Mechanisms of in vivo muscle fatigue in humans: investigating age‐related fatigue resistance with a computational model

DM Callahan, BR Umberger… - The Journal of physiology, 2016 - Wiley Online Library
Key points Muscle fatigue can be defined as the transient decrease in maximal force that
occurs in response to muscle use. Fatigue develops because of a complex set of changes …

Modeling age-related changes in muscle-tendon dynamics during cyclical contractions in the rat gastrocnemius

N Danos, NC Holt, GS Sawicki… - Journal of applied …, 2016 - journals.physiology.org
Efficient muscle-tendon performance during cyclical tasks is dependent on both active and
passive mechanical tissue properties. Here we examine whether age-related changes in the …

Modeling age-related neuromuscular changes in humans

SC Webber, MM Porter… - … Physiology, Nutrition, and …, 2009 - cdnsciencepub.com
With aging, motoneurons and muscle tissue undergo significant changes, which influence
function in terms of strength, mobility, and overall independence. Mathematical modeling …

Rate of force development is Ca2+-dependent and influenced by Ca2+-sensitivity in human single muscle fibres from older adults

N Mazara, DP Zwambag, AM Noonan… - Experimental …, 2021 - Elsevier
Natural adult aging is associated with declines in skeletal muscle performance, including
impaired Ca 2+ sensitivity and a slowing of rapid force production (rate of force …

Aging and the force–velocity relationship of muscles

IS Raj, SR Bird, AJ Shield - Experimental gerontology, 2010 - Elsevier
Aging in humans is associated with a loss in neuromuscular function and performance. This
is related, in part, to the reduction in muscular strength and power caused by a loss of …

[HTML][HTML] Alterations in leg extensor muscle-tendon unit biomechanical properties with ageing and mechanical loading

C McCrum, P Leow, G Epro, M König, K Meijer… - Frontiers in …, 2018 - frontiersin.org
Tendons transfer forces produced by muscle to the skeletal system and can therefore have a
large influence on movement effectiveness and safety. Tendons are mechanosensitive …

The role of muscle strength on tendon adaptability in old age

D Holzer, G Epro, C McCrum, J Doerner… - European journal of …, 2018 - Springer
Purpose The purpose of the study was to determine:(1) the relationship between ankle
plantarflexor muscle strength and Achilles tendon (AT) biomechanical properties in older …

Adjustment of muscle mechanics model parameters to simulate dynamic contractions in older adults

DG Thelen - J. Biomech. Eng., 2003 - asmedigitalcollection.asme.org
The generation of muscle-actuated simulations that accurately represent the movement of
old adults requires a model that accounts for changes in muscle properties that occur with …

Preservation of eccentric strength in older adults: Evidence, mechanisms and implications for training and rehabilitation

M Roig, DL MacIntyre, JJ Eng, MV Narici… - Experimental …, 2010 - Elsevier
Overall reductions in muscle strength typically accompany the aging process. However,
older adults show a relatively preserved capacity of producing eccentric strength. The …