Distinct Gut Microbiota and Arachidonic Acid Metabolism in Obesity-Prone and Obesity-Resistant Mice with a High-Fat Diet

H Zhang, S Chen, L Yang, S Zhang, L Qin, H Jiang - Nutrients, 2024 - mdpi.com
An imbalance of energy intake and expenditure is commonly considered as the fundamental
cause of obesity. However, individual variations in susceptibility to obesity do indeed exist in …

Comparative profiling of gut microbiota and metabolome in diet-induced obese and insulin-resistant C57BL/6J mice

H Aggarwal, J Gautam, D Kumari, SK Gupta… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Diet-based models are commonly used to investigate obesity and related disorders. We
conducted a comparative profiling of three obesogenic diets HFD, high fat diet; HFHF, high …

Gut microbiota affects obesity susceptibility in mice through gut metabolites

Y Wen, Y Luo, H Qiu, B Chen, J Huang, S Lv… - Frontiers in …, 2024 - frontiersin.org
Introduction It is well-known that different populations and animals, even experimental
animals with the same rearing conditions, differ in their susceptibility to obesity. The disparity …

Replication of obesity and associated signaling pathways through transfer of microbiota from obese-prone rats

FA Duca, Y Sakar, P Lepage, F Devime, B Langelier… - Diabetes, 2014 - Am Diabetes Assoc
Aberrations in gut microbiota are associated with metabolic disorders, including obesity.
However, whether shifts in the microbiota profile during obesity are a characteristic of the …

Alterations to the microbiota–colon–brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice

P Zhang, Y Yu, Y Qin, Y Zhou, R Tang, Q Wang… - The Journal of …, 2019 - Elsevier
Obesity is underpinned by both genetic and environmental factors, including a high-
saturated-fat diet. Some mice develop diet-induced obesity (DIO), but others remain diet …

Gut microbiome and metabolome profiles associated with high-fat diet in mice

JK Jo, SH Seo, SE Park, HW Kim, EJ Kim, JS Kim… - Metabolites, 2021 - mdpi.com
Obesity can be caused by microbes producing metabolites; it is thus important to determine
the correlation between gut microbes and metabolites. This study aimed to identify gut …

Metagenomic and metabolomic analyses show correlations between intestinal microbiome diversity and microbiome metabolites in ob/ob and ApoE−/− mice

S Dong, C Wu, W He, R Zhong, J Deng, Y Tao… - Frontiers in …, 2022 - frontiersin.org
Obesity and atherosclerosis are the most prevalent metabolic diseases. The ob/ob and
ApoE-/-mice are widely used as models to study the pathogenesis of these diseases …

Metabolic and gut microbial characterization of obesity-prone mice under a high-fat diet

Y Gu, C Liu, N Zheng, W Jia, W Zhang… - Journal of proteome …, 2019 - ACS Publications
Obesity is characterized with high heterogeneity due to genetic abnormality, energy
imbalance, gut dysbiosis, or a combination of all three. Obesity-prone (OP) and-resistant …

Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet

A Walker, B Pfitzner, S Neschen, M Kahle… - The ISME …, 2014 - academic.oup.com
A combinatory approach using metabolomics and gut microbiome analysis techniques was
performed to unravel the nature and specificity of metabolic profiles related to gut ecology in …

Unique gut microbiome signatures depict diet-versus genetically induced obesity in mice

R Nagpal, SP Mishra, H Yadav - International Journal of Molecular …, 2020 - mdpi.com
The gut microbiome plays an important role in obesity and Type 2 diabetes (T2D); however,
it remains unclear whether the gut microbiome could clarify the dietary versus genetic origin …