▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …

Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the
pathophysiology of this disease shares many similarities with human type 1 diabetes. Since …

The NOD mouse has been an important model of type 1 diabetes and autoimmune diseases
for over 20 years. Experimental and genetic manipulations of the NOD mouse have …

For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …

For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this …

Publisher Summary This chapter summarizes the experimental findings and observations
based on the nonobese diabetic (NOD) mouse model and discusses the pathogenesis and …

Who is more contemptible than he who scorns knowledge of himself?—John of Salisbury
bodies; and the autoreactive T cell dependence of IDDM pathogenesis and the ability to …

The use of animal models to study diseases is fundamental to the advancement of the
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …

T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing β-
cells of the pancreas by the immune system, and is characterized by hyperglycaemia and …