Nonuniform moving boundary method for computational fluid dynamics simulation of intrathecal cerebrospinal flow distribution in a cynomolgus monkey

M Khani, T Xing, C Gibbs… - Journal of …, 2017 - asmedigitalcollection.asme.org
A detailed quantification and understanding of cerebrospinal fluid (CSF) dynamics may
improve detection and treatment of central nervous system (CNS) diseases and help …

Anthropomorphic model of intrathecal cerebrospinal fluid dynamics within the spinal subarachnoid space: spinal cord nerve roots increase steady-streaming

M Khani, LR Sass, T Xing… - Journal of …, 2018 - asmedigitalcollection.asme.org
Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system
(CNS) physiology. The objective of this study was to investigate the impact of spinal cord …

Characterization of the discrepancies between four-dimensional phase-contrast magnetic resonance imaging and in-silico simulations of cerebrospinal fluid dynamics

S Heidari Pahlavian, AC Bunck… - Journal of …, 2015 - asmedigitalcollection.asme.org
The purpose of the present study was to compare subject-specific magnetic resonance
imaging (MRI)-based computational fluid dynamics (CFD) simulations with time-resolved …

Impact of Neurapheresis system on intrathecal cerebrospinal fluid dynamics: a computational fluid dynamics study

M Khani, LR Sass, AR McCabe… - Journal of …, 2020 - asmedigitalcollection.asme.org
It has been hypothesized that early and rapid filtration of blood from cerebrospinal fluid
(CSF) in postsubarachnoid hemorrhage patients may reduce hospital stay and related …

A computational model for the dynamics of cerebrospinal fluid in the spinal subarachnoid space

EF Toro, B Thornber, Q Zhang… - Journal of …, 2019 - asmedigitalcollection.asme.org
Global models for the dynamics of coupled fluid compartments of the central nervous system
(CNS) require simplified representations of the individual components which are both …

A poroelastic fluid/structure-interaction model of cerebrospinal fluid dynamics in the cord with syringomyelia and adjacent subarachnoid-space stenosis

CD Bertram, M Heil - Journal of Biomechanical …, 2017 - asmedigitalcollection.asme.org
An existing axisymmetric fluid/structure-interaction (FSI) model of the spinal cord, pia mater,
subarachnoid space, and dura mater in the presence of syringomyelia and subarachnoid …

Voxelized model of brain infusion that accounts for small feature fissures: comparison with magnetic resonance tracer studies

W Dai, GW Astary… - Journal of …, 2016 - asmedigitalcollection.asme.org
Convection enhanced delivery (CED) is a promising novel technology to treat neural
diseases, as it can transport macromolecular therapeutic agents greater distances through …

Cerebrospinal fluid pressures resulting from experimental traumatic spinal cord injuries in a pig model

CF Jones, JHT Lee, U Burstyn… - Journal of …, 2013 - asmedigitalcollection.asme.org
Despite considerable effort over the last four decades, research has failed to translate into
consistently effective treatment options for spinal cord injury (SCI). This is partly attributed to …

Cerebral blood flow in a healthy Circle of Willis and two intracranial aneurysms: computational fluid dynamics versus four-dimensional phase-contrast magnetic …

P Berg, D Stucht, G Janiga… - Journal of …, 2014 - asmedigitalcollection.asme.org
Computational fluid dynamics (CFD) opens up multiple opportunities to investigate the
hemodynamics of the human vascular system. However, due to numerous assumptions the …

Measurement and Modeling of Transport Across the Blood–Brain Barrier

H Fan, Q Cai, Z Qin - Journal of Biomechanical …, 2023 - asmedigitalcollection.asme.org
The blood–brain barrier (BBB) is a dynamic regulatory barrier at the interface of blood
circulation and the brain parenchyma, which plays a critical role in protecting homeostasis in …