[HTML][HTML] Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams
Human cell-based test methods can be used to evaluate potential hazards of mixtures and
products of petroleum refining (“unknown or variable composition, complex reaction …
products of petroleum refining (“unknown or variable composition, complex reaction …
A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo
Hazard evaluation of substances of “unknown or variable composition, complex reaction
products and biological materials”(UVCBs) remains a major challenge in regulatory science …
products and biological materials”(UVCBs) remains a major challenge in regulatory science …
[HTML][HTML] Grouping of UVCB substances with new approach methodologies (NAMs) data
One of the most challenging areas in regulatory science is assessment of the substances
known as UVCB (unknown or variable composition, complex reaction products and …
known as UVCB (unknown or variable composition, complex reaction products and …
[HTML][HTML] Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays
The application of in vitro biological assays as new approach methodologies (NAMs) to
support grouping of UVCB (unknown or variable composition, complex reaction products …
support grouping of UVCB (unknown or variable composition, complex reaction products …
[HTML][HTML] A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
FA Grimm, Y Iwata, O Sirenko, GA Chappell… - Green chemistry, 2016 - pubs.rsc.org
Comparative assessment of potential human health impacts is a critical step in evaluating
both chemical alternatives and existing products on the market. Most alternatives …
both chemical alternatives and existing products on the market. Most alternatives …
Characterization of compositional variability in petroleum substances
AT Roman-Hubers, AC Cordova, AM Rohde, WA Chiu… - Fuel, 2022 - Elsevier
In the process of registration of substances of Unknown or Variable Composition, Complex
Reaction Products or Biological Materials (UVCBs), information sufficient to enable …
Reaction Products or Biological Materials (UVCBs), information sufficient to enable …
[HTML][HTML] Utility of in vivo metabolomics to support read-across for UVCB substances under REACH
H Kamp, NA Kocabas, F Faulhammer, N Synhaeve… - Archives of …, 2024 - Springer
Abstract Structure-based grouping of chemicals for targeted testing and read-across is an
efficient way to reduce resources and animal usage. For substances of unknown or variable …
efficient way to reduce resources and animal usage. For substances of unknown or variable …
In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances
Determining the in vitro bioavailable concentration is a critical, yet unmet need to refine in
vitro-to-in vivo extrapolation for unknown or variable composition, complex reaction product …
vitro-to-in vivo extrapolation for unknown or variable composition, complex reaction product …
[HTML][HTML] Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization
A detailed characterization of the chemical composition of complex substances, such as
products of petroleum refining and environmental mixtures, is greatly needed in exposure …
products of petroleum refining and environmental mixtures, is greatly needed in exposure …
Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across
Substances of Unknown or Variable composition, Complex reaction products, and Biological
materials (UVCBs), including many refined petroleum products, present a major challenge in …
materials (UVCBs), including many refined petroleum products, present a major challenge in …