The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

Influencing cell behavior from proliferation to differentiation using substrate or implant
topography is an attractive strategy for regenerative medicine applications. Substrate …

The interplay of biophysical and biochemical cues in the extracellular microenvironment
regulate and control the cell fate of stem cells. Understanding the interaction between stem …

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of
stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …

Cells are inherently sensitive to local mesoscale, microscale, and nanoscale patterns of
chemistry and topography. We review current approaches to control cell behavior through …

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

In the area of biomaterials, there has been recent activity in the use of micro-and
nanofabrication technology to alter material surfaces for influencing the attachment and …

Conspectus Over the past decade, there has been growing interest in developing
biosensors and devices with nanoscale and vertical topography. Vertical nanostructures …