Pulmonary fibrosis is a severe and progressive disease that is characterized by an abnormal
deposition of extracellular matrix, such as collagens. The pathogenesis of this disease may …

Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation
and accumulation of extracellular matrix components, is a major therapeutic challenge for …

Ethnopharmacological relevance In the theory of traditional Chinese medicine, pulmonary
fibrosis (PF) belongs to pulmonary arthralgia, which means blood stasis in lung tissue. The …

Apigenin is a non‑toxic and non‑mutagenic flavone that exists abundantly in numerous
herbs and vegetables. Apigenin exerts anti‑proliferative and anti‑inflammatory properties …

Neutrophil elastase plays pivotal roles in the pathogenesis of pulmonary fibrosis. The
neutrophil elastase inhibitor, sivelestat, could alleviate pulmonary fibrosis; however, the …

Aim: Paeoniflorin has shown to attenuate bleomycin-induced pulmonary fibrosis (PF) in
mice. Because the epithelial-mesenchymal transition (EMT) in type 2 lung endothelial cells …

Idiopathic pulmonary fibrosis is a progressive, degenerative and almost irreversible disease.
There is hardly an effective cure for lung damage due to pulmonary fibrosis. The purpose of …

Many studies have reported that bleomycin, anti-cancer drug, induces pulmonary fibrosis as
a side effect. However, few investigations have focused on the dose-response effects of …

Pulmonary fibrosis is a progressive lung disease hallmarked by increased fibroblast
proliferation, amplified levels of extracellular matrix deposition and increased angiogenesis …

To elucidate the pathophysiology of pulmonary fibrosis, we investigated the involvement of
p38 mitogen-activated protein kinase (MAPK), which is one of the major signal transduction …