[HTML][HTML] Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Nanostructured antimicrobial peptides: The last push towards clinics

JV Carratalá, N Serna, A Villaverde, E Vázquez… - Biotechnology …, 2020 - Elsevier
Peptide drugs hold great potential for the treatment of infectious diseases due to their
unconventional mechanisms of action, biocompatibility, biodegradability and ease of …

[HTML][HTML] A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …

[HTML][HTML] A new hope: self-assembling peptides with antimicrobial activity

L Lombardi, A Falanga, V Del Genio, S Galdiero - Pharmaceutics, 2019 - mdpi.com
Peptide drugs hold great promise for the treatment of infectious diseases thanks to their
novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and …

Machine learning-enabled discovery and design of membrane-active peptides

EY Lee, GCL Wong, AL Ferguson - Bioorganic & medicinal chemistry, 2018 - Elsevier
Antimicrobial peptides are a class of membrane-active peptides that form a critical
component of innate host immunity and possess a diversity of sequence and structure …

[HTML][HTML] Evolution of antimicrobial peptides to self-assembled peptides for biomaterial applications

AP McCloskey, BF Gilmore, G Laverty - Pathogens, 2014 - mdpi.com
Biomaterial-related infections are a persistent burden on patient health, recovery, mortality
and healthcare budgets. Self-assembled antimicrobial peptides have evolved from the area …

[HTML][HTML] Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

[HTML][HTML] Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …

Synthetic molecular evolution of antimicrobial peptides

CH Chen, T Bepler, K Pepper, D Fu, TK Lu - Current opinion in …, 2022 - Elsevier
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …