[HTML][HTML] Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …
highly engage into research on alternative strategies to the traditional small molecule …
Nanostructured antimicrobial peptides: The last push towards clinics
Peptide drugs hold great potential for the treatment of infectious diseases due to their
unconventional mechanisms of action, biocompatibility, biodegradability and ease of …
unconventional mechanisms of action, biocompatibility, biodegradability and ease of …
[HTML][HTML] A new era of antibiotics: the clinical potential of antimicrobial peptides
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …
[HTML][HTML] A new hope: self-assembling peptides with antimicrobial activity
Peptide drugs hold great promise for the treatment of infectious diseases thanks to their
novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and …
novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and …
Machine learning-enabled discovery and design of membrane-active peptides
Antimicrobial peptides are a class of membrane-active peptides that form a critical
component of innate host immunity and possess a diversity of sequence and structure …
component of innate host immunity and possess a diversity of sequence and structure …
[HTML][HTML] Evolution of antimicrobial peptides to self-assembled peptides for biomaterial applications
AP McCloskey, BF Gilmore, G Laverty - Pathogens, 2014 - mdpi.com
Biomaterial-related infections are a persistent burden on patient health, recovery, mortality
and healthcare budgets. Self-assembled antimicrobial peptides have evolved from the area …
and healthcare budgets. Self-assembled antimicrobial peptides have evolved from the area …
[HTML][HTML] Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity
L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …
important biomedical applications, specifically in drug delivery and tissue regeneration …
[HTML][HTML] Designing antimicrobial peptides: form follows function
CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications
P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …
Synthetic molecular evolution of antimicrobial peptides
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
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