Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …

The kidney is sensitive to changes in oxygen delivery. This sensitivity has the merit of
facilitating the kidneys in their adjustment of erythropoietin (EPO) production to changes in …

Central to cellular responses to hypoxic environment is the hypoxia-inducible factor (HIF)
transcriptional control system. A role for HIF-2α was investigated in a model of renal …

The hypoxia-inducible transcription factors HIF-1 and HIF-2 mediate key cellular adaptions
to hypoxia and contribute to renal homeostasis and pathophysiology; however, little is …

Role of hypoxia in the pathogenesis of renal disease The kidney shows a remarkable
discrepancy between blood supply and oxygenation. Despite high blood flow and oxygen …

The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial.
Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD …

Tubulointerstitial hypoxia plays a critical role in the pathogenesis of kidney injury, and
hypoxia-inducible factor (HIF)-1 is a master regulator of cellular adaptation to hypoxia. Aside …

Up-regulation of HIF in experimental acute renal failure: Evidence for a protective
transcriptional response to hypoxia. Background Medullary hypoxia is believed to play an …

Hypoxia plays a crucial role in the pathophysiology of acute kidney injury (AKI) and
presumably also chronic kidney disease (CKD). Hypoxia‐inducible factor (HIF) is the master …

Acute renal failure resulting from hypoperfusion and hypoxia is a significant clinical problem.
Hypoxia activates the heterodimeric transcription factor hypoxia inducible factor (HIF) …