The intestinal epithelium constitutes an indispensable single-layered barrier to protect the
body from invading pathogens, antigens or toxins. At the same time, beneficial nutrients and …

Treatment with anti-TNF-α MAb has been accepted as a successful maintenance therapy for
patients with inflammatory bowel diseases (IBD). Moreover, it has been recently reported …

Anti-tumor necrosis factor (TNF) antibodies are successfully used in the therapy of
inflammatory bowel diseases (IBD). However, the molecular mechanism of action of these …

An important function of intestinal epithelial cells (IECs) is to maintain the integrity of the
mucosal barrier. Inflammation challenges the integrity of the mucosal barrier and the …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the
gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) …

Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …

TNF plays an integral role in inflammatory bowel disease (IBD), as evidenced by the
dramatic therapeutic responses in Crohn's disease (CD) patients induced by chimeric anti …

The use of biologic agents, particularly anti-tumor necrosis factor (TNF)-α, has revolutionized
the treatment of inflammatory bowel diseases (IBD), modifying their natural history. Several …

Background and Aims Tumor necrosis factor (TNF) is a cytokine that promotes inflammation
and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and …