Introduction Acute kidney injury following surgery incurs significant mortality with no proven
preventative therapy. We investigated whether the α 2 adrenoceptor agonist …

Introduction One of the main causes of death in European and US intensive care units is
sepsis. It involves a network of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 …

Introduction Sepsis, a systemic inflammatory response to infective etiologies, has a high
mortality rate that is linked both to excess cytokine activity and apoptosis of critical immune …

Background The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs
during critical illness. These drugs may have anti-inflammatory effects, which might be …

Background Early survival following severe injury has been improved with refined
resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among …

Introduction Recent reports have highlighted the prevalence of vitamin D deficiency and
suggested an association with excess mortality in critically ill patients. Serum vitamin D …

Background Renal perfusion status remains poorly studied at the bedside during septic
shock. We sought to measure cortical renal perfusion in patients with septic shock during …

Introduction Only limited information exists on the pharmacokinetics of prolonged (> 24
hours) and high-dose dexmedetomidine infusions in critically ill patients. The aim of this …

Introduction The aim of the study was to evaluate some of the underlying pathomechanisms
of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine …

Purpose The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill
patients remains an understudied area. Previous studies have identified that acute tubular …