The presence of discontinuation symptoms when patients stop taking antidepressants has
sparked heated discussion, both on social media and in the general public press. In the …

The Lancet Psychiatry, Mark Horowitz and David Taylor1 propose that SSRI treatment
should be tapered hyperbolically and slowly, much in the same way as benzodiazepines are …

In The Lancet Psychiatry, David Nutt and colleagues1 stated that headlines such as
“Antidepressants do more harm than good” plumb a “new nadir in irrational polemic.” I …

Mark Horowitz and David Taylor1 share their personal view on tapering of SSRI treatment to
mitigate antidepressant withdrawal symptoms. In the Netherlands, this topic has been …

The meta-analysis by Højlund and colleagues1 does not account for the possibility that the
process of reducing an antipsychotic dose itself, and not a patient merely being on a lower …

Maria Semkovska and colleagues1 did a rigorous metaanalysis of cognitive function in
patients remitted from a major depressive episode (MDE). The results suggest that most …

Comment www. thelancet. com/psychiatry Vol 6 July 2019 553 beneficial effect is the well-
known increase in dropouts due to side-effects, which comes with higher doses. 1–3 On …

The term dependence has come to be used interchangeably with addiction in common
language. 1 This conflation originates from the use of the word dependence to describe …

The Lancet Psychiatry is extremely welcome. However, we urge caution with respect to the
authors' contention that the treatments assessed definitively had no positive effects. In our …

Discontinuation symptoms were only recognised after the SSRIs had been in widespread
clinical use for several years. Initial estimates of prevalence, based on spontaneous adverse …