Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine
production in response to infection and tissue injury. Pattern recognition receptors that are …

Chronic kidney disease (CKD) is a global health concern and public health priority. The
condition often involves inflammation due to the accumulation of toxins and the reduced …

Renal inflammation is a universal response to infectious and noninfectious triggers. Sensors
of the innate immune system, such as Toll-like receptors or RIG-like receptors, provide …

The inflammasome is a multiprotein complex assembled by intracytoplasmic pattern
recognition receptors and is a key component of the innate immune system for host defense …

The NLRP3 inflammasome is an intracellular platform that converts the pro‐inflammatory
cytokines interleukin (IL)‐1β and IL‐18 to their active forms in response to 'danger'signals …

Inflammasomes, multiprotein complex induced by harmful factors in the body, play a crucial
role in innate immunity. Activation of inflammasomes lead to the activation of casepase-1 …

Recent studies in animal models, and limited studies in humans, suggest a broad role for
inflammasome activation in renal disease. Surprisingly, individual components of the …

The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform
involved in innate immunity required for the maturation and release of interleukin (IL)-1β and …

Kidney injury implies danger signaling and a response by the immune system. The
inflammasome is a central danger recognition platform that triggers local and systemic …