The Reproductive-Cell Cycle Theory posits that the hormones that regulate reproduction act
in an antagonistic pleiotrophic manner to control aging via cell cycle signaling; promoting …

A mechanistic understanding of aging has yet to be described; this paper puts forth a new
theory that has the potential to explain aging in all sexually reproductive life forms. The …

The development of a unified conceptual framework for the field of biogerontology has been
impeded by confusing and misleading terminology. Thus, distinctions and definitions are …

Our observation that normal human and animal cells have a limited capacity to divide and
function in vitro overturned a dogma held since the turn of the century. The dogma held that …

Aging is characterized as a breakdown process and the relevant events occur after
reproduction, when the force of natural selection declines. Studies on the life histories of …

Natural selection shapes genomes for reproduction, not for postreproductive survival. One
hypothesis then is that the developmental program, optimized for reproduction, inadvertently …

Reproductive aging in the male occurs in a more subtle and gradual manner than is
observed in females. In humans, there are recordings of individuals in their seventh decade …

Aging in women is a complex process that begins with the transition into reproductive
senescence and evolves to impact not just women's procreative potential but also multiple …

Ovarian ageing is not only of major importance in its own right but is also of interest for its
relationship with the general biology of senescence. A key feature of ageing is the distinction …

A negative correlation between fertility and longevity has been documented in many species
under a variety of conditions, but the association is not always observed, leading to heated …