Identification and Functional Characterization of Adenosine Deaminase in Mucor circinelloides: A Novel Potential Regulator of Nitrogen Utilization and Lipid …

S Li, J Yang, H Mohamed, X Wang, S Pang, C Wu… - Journal of Fungi, 2022 - mdpi.com
Adenosine deaminase (ADA) is an enzyme distributed in a wide variety of organisms that
cleaves adenosine into inosine. Since inosine plays an important role in nitrogen …

Role of AMP Deaminase in Mucor circinelloides: Implications for Nitrogen Utilization and Lipid Biosynthesis

S Li, G Tahiri, J Yang, H Mohamed, Q Liu… - Journal of Agricultural …, 2023 - ACS Publications
Lipid accumulation in oleaginous organisms is initiated by AMP deaminase (AMPD) after
nitrogen depletion because it mediates the concentration of intracellular adenosine …

AMP deaminase: A crucial regulator in nitrogen stress and lipid metabolism in Mucor circinelloides

S Li, J Yang, H Mohamed, X Wang, W Shi, F Xue… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Lipid biosynthesis is a significant metabolic response to nitrogen starvation in oleaginous
fungi. The oleaginous fungus Mucor circinelloides copes with nitrogen stress by degrading …

Role of Adenosine Monophosphate Deaminase during Fatty Acid Accumulation in Oleaginous Fungus Mortierella alpina

L Chang, X Tang, H Lu, H Zhang… - Journal of agricultural …, 2019 - ACS Publications
In oleaginous micro-organisms, nitrogen limitation activates adenosine monophosphate
deaminase (AMPD) and promotes lipogenesis via the inhibition of isocitrate dehydrogenase …

Investigating the Effect of Alcohol Dehydrogenase Gene Knockout on Lipid Accumulation in Mucor circinelloides WJ11

AM Shah, H Mohamed, ABA Fazili, W Yang, Y Song - Journal of Fungi, 2022 - mdpi.com
Mucor circinelloides is an oleaginous, dimorphic zygomycete fungus species that produces
appreciable levels of ethanol when grown under aerobic conditions in the presence of high …

Dissecting metabolic behavior of lipid over-producing strain of Mucor circinelloides through genome-scale metabolic network and multi-level data integration

W Vongsangnak, A Kingkaw, J Yang, Y Song… - Gene, 2018 - Elsevier
Lipid accumulation is an important cellular process of oleaginous microorganisms. To
dissect metabolic behavior of oleaginous Zygomycetes, the lipid over-producing strain …

The role of areA in lipid accumulation in high lipid-producing fungus Mucor circinelloides WJ11

H Hu, P Li, S Li, X Wang, H Mohamed… - … et Biophysica Acta (BBA …, 2024 - Elsevier
In the oleaginous fungus Mucor circinelloides, lipid accumulation is regulated by nitrogen
metabolism, which is regulated by the areA gene, a member of the GATA zinc finger …

Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level

X Tang, X Zan, L Zhao, H Chen, YQ Chen, W Chen… - Microbial cell …, 2016 - Springer
Abstract Background The oleaginous fungus, Mucor circinelloides, is attracting considerable
interest as it produces oil rich in γ-linolenic acid. Nitrogen (N) deficiency is a common …

Transcriptome analysis reveals the molecular mechanisms underlying adenosine biosynthesis in anamorph strain of caterpillar fungus

S Lin, Z Zou, C Zhou, H Zhang… - BioMed research …, 2019 - Wiley Online Library
Caterpillar fungus is a well‐known fungal Chinese medicine. To reveal molecular changes
during early and late stages of adenosine biosynthesis, transcriptome analysis was …

Role of pentose phosphate pathway in lipid accumulation of oleaginous fungus Mucor circinelloides

L Zhao, X Tang, X Luan, H Chen, YQ Chen, W Chen… - RSC …, 2015 - pubs.rsc.org
Lipid biosynthesis in oleaginous fungi requires acetyl-CoA, as the essential precursor of fatty
acids, and a supply of reducing power, NADPH. Malic enzyme provides the majority of …