To survive, cancer cells are subjected to various internal and external adverse factors,
including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these …

Cancer cells must overcome a variety of external and internal stresses to survive and
proliferate. These unfavorable conditions include the accumulation of mutations, nutrient …

The development of biological technologies in genomics, proteomics, and bioinformatics
has led to the identification and characterization of the complete set of coding genes and …

Endoplasmic reticulum (ER) stress has been linked to many diseases, including cancer. A
large body of work has focused on the activation of the ER stress response in cancer cells to …

In eukaryotic cells, the endoplasmic reticulum (ER) is an organelle that is responsible for
protein folding and assembly, lipid and sterol biosynthesis, and free calcium storage. In the …

Cellular disturbances that cause accumulation of misfolded proteins in the endoplasmic
reticulum (ER) lead to a condition referred to as “ER stress” and trigger the unfolded protein …

Cells are exposed to various intrinsic and extrinsic stresses in both physiological and
pathological conditions. To adapt to those conditions, cells have evolved various …

To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …

As the first compartment of the protein secretory pathway, the endoplasmic reticulum (ER)
acts as a protein synthesis factory, maintaining proteostasis and ER homeostasis. However …

Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed
“ER stress” determining the activation of a finely regulated program defined as unfolded …