Diversification of bacterial genome content through distinct mechanisms over different timescales
NJ Croucher, PG Coupland, AE Stevenson… - Nature …, 2014 - nature.com
Bacterial populations often consist of multiple co-circulating lineages. Determining how such
population structures arise requires understanding what drives bacterial diversification …
population structures arise requires understanding what drives bacterial diversification …
Recombination produces coherent bacterial species clusters in both core and accessory genomes
Background: Population samples show bacterial genomes can be divided into a core of
ubiquitous genes and accessory genes that are present in a fraction of isolates. The …
ubiquitous genes and accessory genes that are present in a fraction of isolates. The …
Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
A high-resolution view of genome-wide pneumococcal transformation
Transformation is an important mechanism of microbial evolution through which bacteria
have been observed to rapidly adapt in response to clinical interventions; examples include …
have been observed to rapidly adapt in response to clinical interventions; examples include …
Dense genomic sampling identifies highways of pneumococcal recombination
Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of
non-susceptible genomic variants. We report whole-genome sequencing of 3,085 …
non-susceptible genomic variants. We report whole-genome sequencing of 3,085 …
Core genes can have higher recombination rates than accessory genes within global microbial populations
AP Steinberg, M Lin, E Kussell - Elife, 2022 - elifesciences.org
Recombination is essential to microbial evolution, and is involved in the spread of antibiotic
resistance, antigenic variation, and adaptation to the host niche. However, assessing the …
resistance, antigenic variation, and adaptation to the host niche. However, assessing the …
Whole genome plasticity in pathogenic bacteria
U Dobrindt, J Hacker - Current opinion in microbiology, 2001 - Elsevier
The exploitation of bacterial genome sequences has so far provided a wealth of new
general information about the genetic diversity of bacteria, such as that of many pathogens …
general information about the genetic diversity of bacteria, such as that of many pathogens …
Developing insights into the mechanisms of evolution of bacterial pathogens from whole-genome sequences
Evolution of bacterial pathogen populations has been detected in a variety of ways including
phenotypic tests, such as metabolic activity, reaction to antisera and drug resistance and …
phenotypic tests, such as metabolic activity, reaction to antisera and drug resistance and …
[HTML][HTML] Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae
Streptococcus pneumoniae (the pneumococcus) is a highly recombinogenic bacterium
responsible for a high burden of human disease globally. Genetic recombination, a process …
responsible for a high burden of human disease globally. Genetic recombination, a process …
Toward the use of genomics to study microevolutionary change in bacteria
D Falush - PLoS genetics, 2009 - journals.plos.org
Bacteria evolve rapidly in response to the environment they encounter. Some environmental
changes are experienced numerous times by bacteria from the same population, providing …
changes are experienced numerous times by bacteria from the same population, providing …